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individuals with obesity are 35 times more likely to develop OA [75], and most OA patients undergoing total joint replacement surgery for end-stage OA have obesity or are overweight [76]

A basis of the acanthocytosis in inherited and acquired disorders

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It is unclear to what extent the reduction in lean mass is attributable to loss of skeletal muscle mass per se, which comprises only one component of total body lean mass in mice, but the lack of effect on fat mass is consistent with the reported paucity of IGF-1Rs on mature adipocytes