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doi: 10.1111/j.1365-2036.2005.02658.x 16

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PMID 14223080

IV hydration is firmly established in clinical practice for replacing fluids and electrolytes, and individual nutrients such as B vitamins, vitamin C and magnesium have well-documented roles in energy metabolism, immune function and muscle function

It is known that a widespread characteristic of tumors is their inability to develop adequate blood vessels with the consequence being relative hypoxia: at moderate levels, ROS induce transcription of HIF1, the founding member of the family of hypoxia-induced factors, and stabilize the encoded protein, which is normally hydroxylated within less than 5 min, by inhibiting the activity of the iron-dependent prolyl 4-hydroxylase (PHD) involved in its degradation 29