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The linear fitting afforded R min =1.65, and R max =2.98

doi: 10.1038/nature12820 22 de VosW

In the present study, no clinically significant changes were found in the BMDs of the spine, hip, and total skeleton

Heres what a U-shaped curve looks like (data points are invented for illustration purposes): Photo by Innerbody Research In this invented example, the intervention in question does its best job at reducing a negative biomarker at around 200mg, after which the effect tapers off and soon becomes almost nonexistent

ECL3 and the top of TM7 are tilted slightly away from the peptide, adopting a marginally more open TM bundle than observed in AMYRs