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Overall, these results suggest that Mn overexposure triggers multiple programmed cell death pathways, including apoptosis and ferroptosis, through mitochondrial dysfunction, ER stress, and impaired redox balance

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With more data, healthcare providers can make better treatment decisions and patients can be better informed about potential side effects

In the meantime, pharmacies should prepare to operate under the new rules to ensure a smooth transition once the updated REMS requirements officially begin

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