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Centrally, they manage appetite and cravings by modulating the reward circuitry in the brain, while peripherally, they correct systemic metabolism and reduce hepatic fat accumulation (Jones and Brierley, 2025
Proteins 17 , 31843198 (2025)
miR-1246, released via exosomes from CRC cells, can reprogram tumor-associated macrophages (TAMs) toward a pro-tumor phenotype by altering their metabolic state, thereby supporting CRC growth and immune evasion [115]
Significant weight loss due to modern medications used to treat obesity or diabetes so-called GLP-1 receptor agonists can lead to visible changes in the face
Hydrogels can mimic the brain's extracellular matrix, potentially supporting central nervous system delivery strategies, though blood-brain barrier penetration remains a major technical challenge
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