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Enrollment, follow-up, data analysis, NDA (New Drug Application) preparation, and FDA review typically add up to 18-36 months even with Breakthrough Therapy Designation, which Lilly has received for retatrutide in obesity

Obesity then became the breakthrough market

GLP-1 and Blood Pressure: What the Evidence Shows GLP-1 receptor agonists, primarily licensed for type 2 diabetes and obesity management, have demonstrated modest blood pressure-lowering effects in clinical trials

Meanwhile, participants with severe obesity and established cardiovascular disease in TRIUMPH-3 lost up to 22.6% of their body weight at 80 weeks

Chem databases Jastreboff et al., 2023 (NEJM) LP3-R is referenced in scientific literature as a triple receptor research peptide