Best Pract Res Clin Obstet Gynaecol (2020) 65:3245
Similar findings of behavioral improvement without changes in infarct size have been seen by others, for example, a significant improvement in behavior was seen following treatment with a MEK/ERK inhibitor (U0126) 48 h after ischemia, yet the stroke volume remained unchanged [60]
Peptide Cycling Prevents Receptor Desensitization Just like insulin receptors can become resistant with constant sugar exposure, peptide receptors downregulate if overstimulated
Gao Q, Jia Y, Yang G, Zhang X, Boddu PC, Petersen B, Narsingam S, Zhu YJ, Thimmapaya B, Kanwar YS, Reddy JK (2015) PPARalpha-deficient ob/ob obese mice become more obese and manifest severe hepatic steatosis due to decreased fatty acid oxidation
Pharmacological Reviews, 1998