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Results Dual function of GLP-1 receptor agonist peptide and anti-PCSK9 antibody fusions Based on the critical requirement for a free N-terminus on the GLP-1 peptide for receptor activation 11 , we genetically fused a DPP-4-resistant GLP-1R agonist peptide, similar to the one used in the Fc fusion molecule LY2189265 12 , to either the heavy or light chain variable domain of neutralising anti-PCSK9 antibodies (Fig

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Through these ingenious modications, the drug's half-life can be extended to approximately 7 days

111-148), enacted on March 23, 2010, as amended by the Health Care and Education Reconciliation Act of 2010 (HCERA, Pub

Mean differences between GLP-1 based therapy and control patients in the changes from baseline were 5.47 [9.55, 1.39] mg/dl (P = 0.009