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Consequently, its logical therapeutical applications seems to be limited to restore physiological circulating levels in order to recover the clinical consequences of IGF-I deficiency, conditions where, despite continuous discrepancies, IGF-I treatment has never been related to oncogenesis

It treats unexplained gain during therapy as a signal to investigate rather than something to manage alone, alongside reporting symptoms such as persistent vomiting

and notable increases for the proportion of Enterobacteriaceae , Bacteroidaceae and Porphyromonadaceae compared to baseline levels