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The best outcomes happen when medication is paired with structured lifestyle support

The dose is then increased in 2.5 mg increments no sooner than every 4 weeks, with common maintenance doses of 5, 10, or 15 mg and a maximum of 15 mg once weekly

Why It Works: By increasing fat utilization, tirzepatide helps reduce overall fat stores, especially in stubborn areas like the belly and thighs

It is instructive that the 2021 EUGOGO guidelines include Se supplementation in the treatment regimen for mild GO, recommending a 6-month treatment with Se preparations for patients with mild GO of short duration to prevent the progression to more severe forms of GO (34)

Weight loss plateaus are common after 3 to 6 months on any fixed dose, a phenomenon called metabolic adaptation