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This is possibly linked to the elevation of TMAO levels, a compound associated with cardiovascular risk 1
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GLP-1R, widely distributed in the central nervous system, plays a crucial role in regulating various brain pathological processes, including neuroinflammation, nutrient metabolism, mitochondrial function, and synaptic function [50,51,52]
It was initially used to prevent and treat circulatory disorders, such as strokes, heart attacks, and high blood pressure
However, N-terminal modifications, such as N-acetylation, D-norleucine substitution, or replacement with -aminobutyric acid (GABA), dramatically elongated the peptides half-lives
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