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Overall, the effects of these compounds on fat metabolism, body mass index, lean mass, and insulin sensitivity might show changes in body weight on long-term treatment, yet they are less likely to offer the same results as GLP-1 patches
Across a year and a half of treatment, participants lost an average of 28% of their body weight
However, some patients report nausea from artificial sweeteners, particularly sucralose and aspartame
Tesamorelin, by contrast, occupies an entirely separate category
Retatrutide is the agonist of GLP-1 receptor, GIP receptor, and glucagon (GCG) receptor, which can reduce body weight and improve blood glucose by subcutaneous injection once a week(Rosenstock et al 2023)
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