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Reducing post-surgical fibrosis by modulating IL-8 may be an additional benefit in the multi-disciplinary medical and surgical management of endometriosis. So, if similar beneficial effects are seen in people, this finding could lead to the first disease-modifying treatment for endometriosis

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Arduini, A., Bonomini, M., Savica, V., Amato, A

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In the palmitic acid (PA)-induced ceramide synthase 6 (CERS6)-deficient HK-2 and CERS6 knockdown db/db mouse models, aggravation of DKD symptoms and renal interstitial fibrosis were found, possibly due to the interaction of CERS6-derived ceramide with PINK1 to inhibit PINK1/Parkin-mediated mitophagy, which aggravates DKD [118]