Ignoring pulsatility may lead to inaccurate conclusions regarding receptor sensitivity, downstream pathway activation, and gene expression dynamics
CUMS, chronic unpredictable mild stress
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Rushing this titration or skipping steps increases the likelihood of troublesome digestive symptoms
Chronic stress reduces the appetite-suppressing effectiveness of GLP-1s, and perimenopausal estrogen decline dysregulates the HPA axis that cortisol and GLP-1 mechanisms share, raising baseline cortisol