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Conclusion By focusing on the ROS-related PIPN mechanism, both antioxidant drugs (e.g., small molecular drugs, traditional medicines/active ingredients) and tailor-made nanosystems (e.g., tumor-targeting Pt nanosystems and anti-ROS nanosystems) have demonstrated to be effective in the prevention and treatment of PIPN

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The corresponding graph is presented in figure 7

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Symptoms of B12 deficiency can sometimes occur even when levels fall within the borderline range, which is why clinical correlation with symptoms is essential

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