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Non- compartmental pharmacokinetic parameters were calculated from serum drug concentration- time profiles by use of WinNonlin software (Pharsight, Mountain View, CA, USA)
Experimental protocols: drugs , doses , administration routes
These factors include increased accumulation of advanced glycation end products (AGEs), chronic inflammation due to increased proinflammatory cytokines, and bone microvascular lesions with decreased vascular flow and increased bone fragility
Fast-acting carbohydrate source: Glucose tablets or juice on hand during cycle to address potential hypoglycemia symptoms, especially during dose titration [6]
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