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J Endocrinol 175 : R7R11 Saad MF et al

\Cardiovascular Protection: 26% reduction in major CV events

The half-life of tirzepatide extends approximately 5 days, meaning circadian timing produces minimal clinical differences in glucose control or weight loss outcomes when maintained weekly

While theres no hard evidence that this reduction in temperature is due to the effects of GLP-1 treatment on the hypothalamus, its thought that activating these receptors in the hypothalamus could lower your body temperature, meaning you feel colder

Coxsackievirus infection induces direct pancreatic beta cell killing but poor antiviral CD8(+) T cell responses