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Interventions to modulate NAD + levels Several strategies have been developed to modulate NAD + metabolism, both for mechanistic investigation purposes and to assess their potential therapeutic effects to improve health in aging or disease

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Pickart and colleagues (Nature, 1980, PMID 7453802) reported facilitated copper uptake into cultured cells, and Simon and colleagues (Life Sci, 2000, PMID 11045606) reported upregulated MMP-2 alongside its tissue inhibitors in fibroblast culture