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Most clinical evidence is topical

Influence on Appetite During preclinical trials on non-human test subjects, the Tirzepatide peptide has shown a promising impact on appetite

Some of these papers have not been formally retracted

Neither is a replacement for the primary papers, but both are useful orientation for researchers who need the class context before diving into compound-specific mechanism work

1.3.2 Lipid-based nanosystems Lipid-based NPs have a demonstrated track record, have suitable biological properties, including biocompatibility and biodegradability, and are suitable for both hydrophobic and hydrophilic drugs [115]