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Its mechanism appears to involve the activation of the Akt/NOS/NF-B signaling pathway (Yang et al., 2018)

Weight reduction remains an elusive goal for many people with T2D

Semaglutide mimics and amplifies this hormone, producing sustained appetite suppression over the course of a week from a single injection

PMID: 25905171 Rody AK et al (1999): Regulation of androgen action

However, it needs: A lifetime of weekly shots to sustain its effects $1,000-$1,400 per month The weight comes back after you stop taking it Up to 18-22% reduction of body weight compared to 30-35% for gastric bypass surgery When considering lifelong treatment and people with a BMI of at least 35, bariatric surgery allows one to lose more weight AND no injections are required anymore