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Rarely, patients may experience hypersensitivity reactions to cobalt or vitamin B12, including rash, itching, acneiform eruptions, or in exceptional cases, anaphylaxis

It is driven by excessive energy expenditure, catabolism, and inflammation linked to increased proinflammatory cytokines, enhanced proteasomic muscle degradation, and significant lipolysis [ 9 ]

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Scientific commentary on:comprehensive proteomics of CSF, plasma and urine identify DDC and other biomarkers of early Parkinsons disease. Acta Neuropathol 147(1):88

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