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Sanjay Kaul, a frequent FDA advisor, pointed out the paradox of the large commercial success of the diabetes drugs despite the absence of any proven clinical benefit: "So, we have a drug that yields modest glycemic efficacy, is neutral with respect to cardiometabolic factors (lipids, weight, blood pressure), does not kill you or land you in a hospital, and yet is a blockbuster drug nearly 5 times over

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As mentioned, if not treated otherwise, duodenocutaneous fistulas exhibited poor healing (Tables 1-5 , Fig

Its once-weekly profile and strong clinical data are major reasons it has become so widely discussed in metabolic medicine

One could probably turn the tables and and