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Effects of SGLT2 inhibitors on UTIs and genital infections in type 2 diabetes mellitus: a systematic review and meta-analysis

| | COX-2 Selective Inhibitors (e.g., Celecoxib) | Cyclooxygenase-2 (COX-2) only [5] [8] [7] | Reduces inflammatory prostaglandins while largely sparing protective prostaglandins in gut and kidneys [5] [8] [7] | Clinical use in humans for arthritis and pain [5]

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Activation of PKA inhibits Akt phosphorylation in cortical neurons, whereas activation of Epac induces Akt phosphorylation mediated through Rap activation emphasizing cAMP/Epac/Akt signaling pathway (Nijholt et al., 2008)

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