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8.8%) These results are published in The New England Journal of Medicine (Wharton et al., 2025) and represent the strongest weight loss data ever seen from an oral GLP-1 candidate in Phase 3 trials

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Horsk, A

To reduce the number of steps in a sample preparation procedure a simultaneous reduction of disulfide bound with tris(2-carboxyethyl)phosphine (TCEP) and the selective pre-column derivatization of the thiol group with 1-benzyl-2-chloropyridinium bromide (BCPB) has been applied