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showed that supplementation with Bifidobacterium longum NCC3001 (BL) at a dose of 1 10 10 CFU/day for 4 weeks improves depression-like symptoms (reduced BDI-II score by 3.2 points) and quality of life (increased IBS-QoL score by 15%) in IBS patients with comorbid depressive symptoms ( Summary of core mechanisms: dietary fiber increased abundance of gut microbiota ( Bifidobacterium / Lactobacillus ) enhanced SCFA production mood regulation via the gut-brain axis alleviation of depressive symptoms (Figure 2)

Glucagon-Like Peptide 1 Secretion by the L-Cell

The co-expression of GLP-1R, glucokinase, and glucose transporter protein 2 (GLUT-2) in the neurons involved in the control of food intake suggests that these cells may play a role in glucose sensing in the brain [14, 16-19]

Effects of low-dose prenatal corticosteroid administration on the premature rat