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The more relevant research question is whether triple receptor agonism (GIP + GLP-1 + glucagon) combining elements of both approaches could outperform either dual agonist

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[113] We're including niacinamide , but aren't using a huge dose like some pre-workouts because it could cause annoying flushing

doi: 10.1038/S41579-022-00846-2 10 RandoHMBennettTDByrdJBBramanteCCallahanTJChuteCGet al

The initial inflammatory modulation begins within the first one to two weeks, but the functional changes, including improved flexibility, reduced global stiffness, and better circulation, accumulate over four to eight weeks as the compounds systemic effects build through repeated dosing