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D-mannose regulates hepatocyte lipid metabolism via PI3K/Akt/mTOR signaling pathway and ameliorates hepatic steatosis in alcoholic liver disease

Use of GLP-1 receptor agonists was associated with lower rates of invasive pain-related procedures

In TRPML1-deficient mice, an increase in p62 and a clearance defect in LC3-II were found, which shows that the complete autophagy flux was destroyed (Curcio-Morelli et al., 2010)

In these cases, pausing at an intermediate dose level often provides optimal benefits without excess discomfort

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