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And Lilly's other weight loss drug, tirzepatide, was shown to reduce body weight, on average, by 22.5% on average, or about 52 pounds, after 72 weeks

or for other reasons are at particularly high risk of negative consequences from misinterpreted UDS results

Documented doses are animal-only: ~1.44-2.88 mg/kg oral in mice

Mechanistically, GLP-1 RAs exhibit renoprotective effects by reducing oxidative stress, inflammation, and fibrosis, processes central to the pathogenesis of AS [1, 3]