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Semaglutide also significantly improved modifiable CV risk factors, reducing systolic/diastolic blood pressure (SBP/DBP) decreased by 8.02/3.71 mmHg, and low-density Lipoprotein (LDL) decreased by 12.62 mg/dL, while increasing high-density lipoprotein (HDL) by 1.44 mg/dL

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A larger February 2025 study analyzing 37.1 million adults with diabetes across 14 databases found semaglutide users had more than 4 times greater risk of NAION compared to non-GLP-1 drugs, with an incidence rate ratio of 1.32