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This nanoagent was self-assembled by photosensitizer Ce6 for 1 O 2 production and Fe 3+ for GSH consumption, encapsulated with polyvinylpyrrolidone (PVP) polymer, named Mn 3 [Fe(CN) 6 ] 2 -Ce 6 nanoagent (Glud-MFo-c)

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Previous studies have demonstrated that 11-HSD1 is expressed in the anterior pituitary, paraventricular nucleus, and hypothalamus within the central nervous system, all of which are involved in the regulation of the HPA axis 27,28

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