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The combined effect might prove intolerable and lead to dehydration, electrolyte imbalances, or poor medication adherence
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and (d) not interfere with the bodys normal functions more than is necessary [64]
Subsequent analysis using the UK Biobank dataset not only confirmed this finding but also revealed an association between the causal SNP in the GPR146 locus, rs1997243, and C-reactive protein (CRP) levels, as well as plasma liver enzymes, including gamma glutamyl-transferase (GGT), aspartate transaminase (AST), and alkaline phosphatase (ALP) 16,17
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