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247 Mechanistically, it is unclear how GLP-1-based therapies exert beneficial effects on the cardiovascular system, but studies have suggested that this is achieved by direct (cardiovascular GLP-1R activation) and indirect (promotion of the incretin effect) mechanisms

Mice also developed skin irritation and graying of the fur that was reversed with pantothenic acid administration

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity