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Suggested phrasing: preferred wording: Not recommended outside strict indications (ideally within research protocols) and requires time-bounded use with explicit contraception and washout planning. This avoids absolute prohibition while still signaling the expected standard of care

When to Consult Your Provider and Personalization Through Genetics Constipation lasting more than two weeks, accompanied by abdominal pain, blood in stool, or weight loss warrants medical evaluation

All the studies are summarized in Table 2

Jacobs, P