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The theoretical concern is valid: chronic MC1R overstimulation could, in principle, drive melanocyte proliferation without the UV-induced apoptosis that normally limits melanogenesis

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J Biol Chem 277:1965819664 Tydell CC, Yuan J, Tran P, Selsted ME (2006) Bovine Peptidoglycan recognition protein-S: antimicrobial activity, localization, secretion, and binding properties