The phosphorylation leads downregulation of MTHFR activity and upregulation of allosteric inhibition by SAM
These negative effects have been shown to be attenuated by antihypertensive [52] and antidiabetic [47,49] drugs, among others [48,50,51]
GLP-1 Antidiabetic Medications Glucagon-like Peptide-1 (GLP-1) agonists are injectable medications used to treat Type 2 diabetes and may also cause weight loss
The keywords used in the literature search included design, synthesis, DPP-4 inhibitors, docking, and structure-activity relationship. Initially, 200 papers were evaluated, with duplicates and publications unrelated to the searchs objective discarded
PMID: 133 KunickaZMierzejewskiKKurzyskaAStryiskiRMateosJCarreraMet al