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The medication's mechanism of action involves binding to GLP-1 receptors in the hypothalamus, reducing hunger signals and increasing feelings of fullness

The PMC case report documents allodynia with tirzepatide, which is a dual GIP/GLP-1 receptor agonist rather than a pure GLP-1 agonist

These combined effects help regulate blood sugar and may contribute to weight loss, which in turn can further improve blood glucose control and reduce other health risks

But even those who had underlying conditions tended to say their decision to use a GLP-1 was triggered by a desire to lose a relatively minor amount of weight

The regularly scheduled day can be changed if necessary, as long as the time between two doses is at least 2 days (48 hours)