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10 Furthermore, it has been shown that claudin-5 and occludin are decreased in mice with HE

The results of this trial show that both drugs alone and in combination demonstrate improvements in appetite suppression, fullness, and satiety

Chem Biol Inter 129:6176 Van den Berg M, Sanderson T, Kurihara N, Katayama A (2003) Role of metabolism in the endocrine-disrupting effects of chemicals in aquatic and terrestrial systems

This phenomenon, known as the somatopause, is also seen in other mammals and has led to the speculation that GH treatment can be a potent anti-aging therapy (467)