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Retatrutide (LY3437943) simultaneously activates GLP-1, GIP, and glucagon receptors, making it pharmacologically distinct from semaglutide or tirzepatide

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As of mid-2025, the FDA documented 605 adverse event reports specifically related to compounded semaglutide

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It represents a new class of therapies called triple agonists, meaning it simultaneously activates three key hormone receptors: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon

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In animal studies, it seems to help tendons and ligaments heal faster, grow new blood vessels in hurt areas, calm down inflammation, and protect the stomach lining

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