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Wegovy (semaglutide) is a once-weekly prescription medication that helps with weight management and lowers the risk of cardiovascular events

Weight loss failure on tirzepatide usually traces back to insufficient dose (need to escalate further), caloric intake still exceeding expenditure despite reduced appetite, metabolic adaptation, or underlying medical conditions like hypothyroidism or PCOS that require separate treatment

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the two constituent studies had an SMD of 1.10 (95% CI 1.37 to 0.83) and were homogeneous (I = 0%)

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