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Great efforts are still needed in the future to develop delivery particles that are low in immunogenicity and can act directly on target tissues

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Our study provides evidence and identifies myocyte-specific mechanisms to challenge existing paradigms for glucocorticoid drugs with unexpected antisarcopenic effects

Over the next years, it will be important to understand the effect of the reduced circulating amino-acids with the novel multi-agonists targeting the glucagon receptor on lean muscle mass (especially in populations with obesity and high risk of sarcopenia) as well as on energy expenditure [66]

The potential benefits aren't just additive