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[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Man G.S., Mologhianu G

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Human growth hormone is composed of 4 major -helices which are arranged in an up-up-down-down topology required for receptor interaction along with three mini helices.18 A C-terminal hGH fragment 176191 with a tyrosine to phenylalanine substitution at the last position has been reported to enhance lipid breakdown and fat utilization in mice.1921 And hence, in the present study we examined if hGH fragment 176191 peptide can facilitate the anticancer efficacy of doxorubicin-loaded nanoparticles