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Trial evidence: Tesamorelin 2mg SC daily sustained GH/IGF-1 elevation, 15-18% visceral fat reduction over 6 months (Falutz, NEJM 2007, PMID 17699044) Ipamorelin 200-300 mcg peak GH 5-10x baseline within 30 minutes, no cortisol/prolactin bump (Raun, EJE 1998, PMID 9539826) GHRH + GHRP synergy 2-3x greater amplitude than either alone (Bowers, JCEM 1991, PMID 2004615) Community protocols extend this evidence base with cycling patterns that weren't studied in the original trials the 5-on/2-off rhythm and 8-week cycles are empirical community consensus, not clinically validated

Anti-inflammatory Effects : Growth hormone (HGH) has some anti-inflammatory properties, which can help reduce inflammation in injured tissues and support the repair process

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Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats

doi: 10.1038/s41598-017-13070-3 147 MorrisonAISjoerdsMJVonkLAGibbsSKoningJJ