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The Golden Era of GLP-1 Drugs GLP-1 RAs are entero-pancreatic hormone-based treatments, first approved in 2005 for type 2 diabetes (T2D), and now commonly prescribed for weight loss and reduction of atherosclerotic cardiovascular (CV) risk in patients with T2D

Since IGFBPs normally sequester most circulating IGF-1, this escape from binding protein control creates much higher free (bioactive) concentrations at the injection site

That dual action matters because the two pathways do different things

Think of it as your skin's personal bodyguard and renovation crew rolled into one