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MOTS-c treatment alone was able to improve glucose tolerance in NOD mice, to a level similar to that of exendin-4 treatment (Fig

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The short half-life of native GLP-1, typically only 12 min due to rapid degradation, has facilitated the development of structurally modified GLP-1 analogs with longer half-lives, such as liraglutide, exendin-4, and dulaglutide, which exhibit 97%, 53%, and 90% sequence homology, respectively 12

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