In experimental studies, it has been shown to enhance healing of various wounds, including gastric ulcers, skin, cornea, muscle, colon-colon anastomosis, colo-rectal fistula, and segmental bone defects
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Atrophic gastritis, a condition that depletes stomach acid, also reduces B12 absorption
8,9 Table 1 Risk Factors for Vitamin B12 Deficiency A multicenter randomized controlled trial of 390 patients with diabetes mellitus showed that those taking 850 mg of metformin three times per day had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years) vs