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Research in Photodermatology, Photoimmunology & Photomedicine demonstrated that polypodium supplementation enhanced the skins defenses against UV radiation, thereby reducing hyperpigmentation in melasma patients

While generally well-tolerated, some people may experience mild side effects such as bloating, cramps, or allergic reactions

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Prescott LF, Illingworth RN, Critchley JJH, Stewart MJ, Adam RD, Proudfoot AT: Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning