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In addition, hyperandrogenism by itself stimulates the deposition of adipose tissue in the visceral area, with further increase in insulin resistance, thus contributing to the vicious circle [17]

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We found that GLP-1R knockdown significantly decreased the proliferation of CFPAC-1 cells after 4 days of culture when using siGLP-1R 4, and after 5 days of culture when using both siGLP-1R 4 and siGLP-1R 5, as compared with siControl (Fig