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Alpha-blockers and PDE5-inhibitors relax the smooth muscle of prostate and portions of the bladder, while 5-alpha reductase inhibitors shrink the prostate

Fernandes L, Hagen KB, Bijlsma JW, Andreassen O, Christensen P, Conaghan PG, Doherty M, Geenen R, Hammond A, Kjeken I, Lohmander LS, Lund H, Mallen CD, Nava T, Oliver S, Pavelka K, Pitsillidou I, da Silva JA, de la Torre J, Zanoli G, Vliet Vlieland TP (2013) European League Against R EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis

However, factors like aging, poor nutrition, and environmental toxins can deplete our natural levels

Diabetologia 59(10):21562165

Our study has a few limitations