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Furthermore, studies have examined these effects in fibroblast and keratinocyte cultures, endothelial and neuronal systems, and preclinical animal models related to wound repair and tissue response

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[DOI] [PubMed] [Google Scholar] 2.Salim S., Kamalasanan K

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Retrograde signaling with nitric oxide at neocortical synapses

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2015;309(5):H86779

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(2) preclinical-to-clinical gaps persist in dose optimization (e.g., PK/PD modeling for febuxostatSEDDSs) and delivery route validation (e.g., human skin studies for elastic liposomes), with limited data on patient compliance and real-world applicability

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