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In mitigating oxidative stress, glucose metabolism is rewired to the PPP that operates parallel to glycolysis to maintain redox homeostasis by generating ribose-5-phosphate and NADPH [11]

To test whether Gipr antagonism affects energy metabolism via a similar mechanism, we treated DIO Vgat-Cre + Gipr wt/wt (WT) and Vgat-Cre + Gipr flx/flx ( Vgat-Gipr knockout (KO)) mice for 24 days with either vehicle, a long-acting GLP-1R agonist (acyl-GLP-1, 10 nmol kg 1 ) 13,14,15 or the combination of acyl-GLP-1 (10 nmol kg 1 ) and a validated long-acting (acylated) peptide GIPR antagonist (1,500 nmol kg 1 ) 22

About this article Cite this article Siddiqui, H.F., Waqas, S.A., Batool, R.M